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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Bioessays. 2023 Feb 15;45(4):e2200191. doi: 10.1002/bies.202200191
Method
Original definition: a test involving experiments on organisms.[5]
New definition: a procedure to experiment on an organism or material derived from an organism, or to produce or purify a substance(s) for such purpose.
Screen
Original definition: the sort of physical examination of the child which will recognize deviations from the normal, but which will not result in a final diagnosis.
New definition: A scalable biological or medical experimental method for surveying a group to enrich for likely candidates that can be confirmed with an assay.
Assay
Original definition: to compare the potency of the particular preparation test with that of a standard preparation of the same substance.
New definition: A biological or medical experimental method to compare samples to known negative and positive standards with high statistical accuracy.
Fabrication
New definition: A method to create or purify a new reagent.
HAT Assay
New definition: High-accuracy and high-throughput assay.