Summary of findings 2. Armodafinil versus placebo for sleepiness caused by shift work.
| Armodafinil versus placebo for sleepiness caused by shift work | |||||
| Patient or population: patients with sleepiness caused by shift work Settings: work setting Intervention: Armodafinil versus placebo | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (trials) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| Control | Armodafinil versus placebo | ||||
|
Sleepiness during the night shift
KSS at final visit. Scale from: 1 to 9. Follow‐up: mean 3 months |
The mean sleepiness during the night shift in the control groups was 6 score points of KSS | The mean sleepiness during the night shift in the intervention groups was 0.99 lower (1.32 to 0.67 lower) | ‐ | 572 (2 trials) | ⊕⊕⊕⊝ moderate1 |
|
Sleep latency
MSLT. Scale from: 0 to 20 minutes. Follow‐up: mean 3 months |
The mean sleep latency in the control groups was 5.3 minutes on MSLT | The mean sleep latency in the intervention groups was 2.5 higher (1.36 to 3.64 higher) | ‐ | 216 (1 trial) | ⊕⊕⊝⊝ low2,3 |
| *The basis for the assumed risk (e.g. the median control group risk across trials) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; Karolinska Sleepiness Scale (KSS); Multiple sleep latency test (MSLT). | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1 We included one trial at unclear risk of bias and one at low risk of bias. 2 This is a laboratory test and not a field test. 3 There was only one included trial.