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. 2023 Mar 4;62:102657. doi: 10.1016/j.redox.2023.102657

Fig. 1.

Fig. 1

Evaluation of endothelial function in mouse aorta rings incubated with AP123 during hyperglycemia. (A) Vasodilating effect exerted by Acetylcholine (Ach), AP123 and vehicle (DMSO) in aorta rings (n = 5) **p < 0.01 vs. vehicle and AP123. The Ach exerts a relaxant effect depending upon the concentrations used (1nM-3μM); conversely, neither AP123 nor DMSO triggers vasodilation when used within the same concentration range (1nM-3μM). (B) Ach-induced vasorelaxation in aorta rings incubated with AP123 (10–100 nM) exposed to HG or NG environment for 20 h **p < 0.01 vs. NG; ###p < 0.001 vs HG. Differences have been considered statistically significant when p was ≤0.05.