Fig. 5.

Role of CSE-derived H₂S in aorta from CSE^−/−mice. (A) Western blot and densitometric analysis showing cropped images of CREB expression in the aorta harvested from CSE^−/− and WT mice. (B) Ach-induced vasorelaxation in aorta rings harvested from CSE^−/− and WT mice and Ach-induced vasorelaxation in aorta rings harvested from CSE^−/− incubated with AP123 (20 h, 10 nM). The graphs represent the mean ± SEM for each group (n = 4–5). The GAPDH has been used as a housekeeping control protein ***p < 0.001 vs. WT. ^###p < 0.001 vs CSE^−/−. Differences have been considered statistically significant when p was ≤0.05.