Fig. 1.

WT SS mice have a significant increase in plasma XO activity in response to hemin crisis. A) Experimental design. Complete blood counts shown as a delta change from baseline to 24 h post-hemin challenge including B) red blood cells, C) hematocrit, and D) hemoglobin. E) Plasma XO activity was measured using HPLC as a delta change from baseline to 24 h post-hemin challenge. Values are mean ± SEM using an unpaired Student t-test unless otherwise noted. ^#Values are mean ± SEM using a Mann Whitney test. WT, wildtype; XO, xanthine oxidase; HPLC, high performance liquid chromatography. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)