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. 2023 Mar 8;62:102661. doi: 10.1016/j.redox.2023.102661

Fig. 4.

Fig. 4

Cholesterol safeguards HSC maintenance and myeloid regeneration during irradiation-induced myelosuppression. (A) LT-HSC numbers in BM of CD and HCD mice post IR (n = 4). (B–D) White blood cell (WBC), red blood cell (RBC), and platelet counts in PB of CD and HCD mice post IR (n = 6). (E) Serum LDL-C levels in CD and HCD mice post IR (n = 3). (F and G) Flow cytometric analysis of intracellular cholesterol contents and LDLR surface expression in BM LT-HSCs of CD and HCD mice post IR (n = 3). (H) Frequency of Fr2 LT-HSCs in BM of CD and HCD mice post IR (n = 4). (I) Survival analysis of CD and HCD mice after lethal IR (7.5 Gy) exposure (n = 10). Data are mean ± SD. n.s., not significant. *p < 0.05, **p < 0.01, IR + HCD group compared with IR group. Two-tailed unpaired Student’s t-test unless stated otherwise. Kaplan–Meier survival curves and log-rank test (I). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)