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. 2023 Mar 8;62:102661. doi: 10.1016/j.redox.2023.102661

Fig. 9.

Fig. 9

Ferroptosis inducer administration restores maintenance and differentiation balance of HSCs in HCD mice. (A) GSH and GSSG contents in BM LT-HSCs of HCD mice with or without IKE treatment (n = 3). (B–D) Flow cytometric analysis of GPX4 expression (B), ferrous ion deposition (C) and ferritin expression (D) in BM LT-HSCs of HCD mice with or without IKE treatment (n = 4). (E–F) Ferroptosis resistance analysis of LT-HSCs from HCD mice with or without IKE treatment (n = 4). (G) Flow cytometric analysis of LT-HSC pool size in HCD mice with or without IKE treatment (n = 4). (H) Frequencies of T cells, B cells, and myeloid cells in PB and BM of HCD mice with or without IKE treatment (n = 4). (I) Frequency of LT-HSC subpopulations in BM of HCD mice with or without IKE treatment (n = 4). Data are mean ± SD. n.s., not significant. *p < 0.05, **p < 0.01. Two-tailed unpaired Student’s t-test.