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. 2022 Sep 27;72(4):917–928. doi: 10.1007/s00262-022-03290-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Diagrams of F3M CAR and LCAR-M23. a Diagram of F3M CAR is shown. F3M CAR consists of a human CD8α SP, humanized anti-MSLNsdAb (clone F3M), a human CD8α hinge + TM domain, a human 4-1BB cytoplasmic domain, and a human CD3ζ cytoplasmic domain. b Diagram of LCAR-M23 is shown. LCAR-M23 consists of dnTGFβRII and F3M CAR CD3ζ, cluster of differentiation 3 zeta; CD8α hinge + TM, cluster of differentiation 8 alpha hinge and transmembrane; CD8α SP, cluster of differentiation 8 alpha signal peptide; dnTGFβRII, dominant-negative transforming growth factor-β receptor type II; ICD, intracellular domain; MSLN, mesothelin; sdAb, single-domain antibody