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. 2022 Sep 27;72(4):917–928. doi: 10.1007/s00262-022-03290-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Evaluation of in vivo efficacy of LCAR-M23 CAR T cells. a The tumour-bearing mice were randomly assigned to five groups. Tumour growth from dose escalation of LCAR-M23 CAR T cells in an OVCAR-3 xenograft mouse model. b Tumour growth from vector control, UnT control and LCAR-M23 CAR T treatment in the PDX models of ovarian carcinoma. LCAR-M23 CAR T cells significantly reduced ovarian cancer burden in the PDX models. Data shown in a–b are at least 3 mice in each group (mean ± SEM). *p < 0.05 ** p < 0.01, *** p < 0.001