Fig. 7.

In vitro RPFs based on PROAST dose–response analysis of PDK4, HMGCR, OAT5, and THRSP gene expression data obtained from HepaRG cells exposed to various PFASs. RPFs are presented as vertical lines, with the 5% lower bound and 95% upper bound of the confidence interval as whiskers. PFOA was used as index chemical, i.e., has an RPF of 1 (dotted line). NA not applicable, RPF could not be determined