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. 2022 Oct 1;72(4):929–944. doi: 10.1007/s00262-022-03301-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Changes in several biomarkers. a Values of sIL-2R and the percentages of abnormal lymphocytes in peripheral blood in indolent-type ATLL patients. Green lines: sIL-2R (U/L). Red lines: abnormal lymphocytes (abn-Ly) per white blood cells in peripheral blood (%). The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. b HTLV-1 provirus load (copies/1000PBMNCs) and the percentages of CD4- and CD8-positive T lymphocytes in peripheral blood in indolent-type ATLL patients. Green lines: HTLV-1 provirus load (copies/1000PBMNCs). Blue lines: CD4⁺ T cells per lymphocytes in peripheral blood (%). Red lines: CD8⁺ T cells per lymphocytes in peripheral blood (%). The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. c Values of sIL-2R and the percentages of abnormal lymphocytes in peripheral blood in aggressive-type ATLL patients. Green lines: sIL-2R (U/L). Red lines: abnormal lymphocytes (abn-Ly) per white blood cells in peripheral blood (%). The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. d HTLV-1 provirus load (copies/1000PBMNCs) and the percentages of CD4- and CD8-positive T lymphocytes in aggressive-type ATLL patients. Green lines: HTLV-1 provirus load (copies/1000PBMNCs). Blue lines: CD4⁺ T cells per lymphocytes in peripheral blood (%). Red lines: CD8⁺ T cells per lymphocytes in peripheral blood (%). The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. 1st Vac., first VZV vaccination; 2nd Vac., second VZV vaccination

Fig. 3 — Changes in several biomarkers. a Values of sIL-2R and the percentages of abnormal lymphocytes in peripheral blood in indolent-type ATLL patients. Green lines: sIL-2R (U/L). Red lines: abnormal lymphocytes (abn-Ly) per white blood cells in peripheral blood (%). The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. b HTLV-1 provirus load (copies/1000PBMNCs) and the percentages of CD4- and CD8-positive T lymphocytes in peripheral blood in indolent-type ATLL patients. Green lines: HTLV-1 provirus load (copies/1000PBMNCs). Blue lines: CD4⁺ T cells per lymphocytes in peripheral blood (%). Red lines: CD8⁺ T cells per lymphocytes in peripheral blood (%). The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. c Values of sIL-2R and the percentages of abnormal lymphocytes in peripheral blood in aggressive-type ATLL patients. Green lines: sIL-2R (U/L). Red lines: abnormal lymphocytes (abn-Ly) per white blood cells in peripheral blood (%). The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. d HTLV-1 provirus load (copies/1000PBMNCs) and the percentages of CD4- and CD8-positive T lymphocytes in aggressive-type ATLL patients. Green lines: HTLV-1 provirus load (copies/1000PBMNCs). Blue lines: CD4⁺ T cells per lymphocytes in peripheral blood (%). Red lines: CD8⁺ T cells per lymphocytes in peripheral blood (%). The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. 1st Vac., first VZV vaccination; 2nd Vac., second VZV vaccination