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. 2022 Oct 1;72(4):929–944. doi: 10.1007/s00262-022-03301-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Changes in VZV skin test, VZV-specific CD8⁺ T cells, and VZV-specific CD4⁺ memory T cells. a VZV skin test and VZV-specific CD8⁺ T cells in the indolent-type ATLL patients. The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. Green bar: the major axis (millimeter) of skin redness by VZV skin test. Red lines: percentages of VZV-specific CD8⁺ memory T cells (CD3⁺CD4⁻CD45RA⁻RO⁺ population) in CD8-positive T lymphocytes. Blue lines: percentages of VZV-specific CD8⁺ effector T cells (CD3⁺CD4⁻CD45RA⁺RO⁺ population) in CD8-positive T lymphocytes. b VZV skin test and VZV-specific CD8⁺ T cells in the aggressive-type ATLL patients. The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. Green bar: the major axis (millimeter) of skin redness by VZV skin test. Red lines: percentages of VZV-specific CD8⁺ memory T cells (CD3⁺CD4⁻CD45RA⁻RO⁺ population) in CD8-positiveT lymphocytes. Blue lines: percentages of VZV-specific CD8⁺ effector T cells (CD3⁺CD4⁻CD45RA⁺RO⁺ population) in CD8-positive T lymphocytes. c VZV-specific CD4⁺ memory T cells in indolent-type ATLL patients. The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. d VZV-specific CD4⁺ memory T cells in aggressive-type ATLL patients. The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. 1st Vac., First VZV vaccination; 2nd Vac., Second VZV vaccination

Fig. 5 — Changes in VZV skin test, VZV-specific CD8⁺ T cells, and VZV-specific CD4⁺ memory T cells. a VZV skin test and VZV-specific CD8⁺ T cells in the indolent-type ATLL patients. The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. Green bar: the major axis (millimeter) of skin redness by VZV skin test. Red lines: percentages of VZV-specific CD8⁺ memory T cells (CD3⁺CD4⁻CD45RA⁻RO⁺ population) in CD8-positive T lymphocytes. Blue lines: percentages of VZV-specific CD8⁺ effector T cells (CD3⁺CD4⁻CD45RA⁺RO⁺ population) in CD8-positive T lymphocytes. b VZV skin test and VZV-specific CD8⁺ T cells in the aggressive-type ATLL patients. The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. Green bar: the major axis (millimeter) of skin redness by VZV skin test. Red lines: percentages of VZV-specific CD8⁺ memory T cells (CD3⁺CD4⁻CD45RA⁻RO⁺ population) in CD8-positiveT lymphocytes. Blue lines: percentages of VZV-specific CD8⁺ effector T cells (CD3⁺CD4⁻CD45RA⁺RO⁺ population) in CD8-positive T lymphocytes. c VZV-specific CD4⁺ memory T cells in indolent-type ATLL patients. The upper, middle, and lower panels indicate data of Indolent-1, Indolent-2, and Indolent-3, respectively. d VZV-specific CD4⁺ memory T cells in aggressive-type ATLL patients. The upper, middle, and lower panels indicate data of Aggressive-1, Aggressive-2, and Aggressive-3, respectively. 1st Vac., First VZV vaccination; 2nd Vac., Second VZV vaccination