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. 2023 Mar 6;14:1138658. doi: 10.3389/fphar.2023.1138658

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Copyright © 2023 Xu, Pan, Wang, Wang, Tang, Dong and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD treatment affects cell division and cell cycle progression based on RNA-seq analysis. (A) GSEA analysis of the DNA replication in PD-treated (10 μM) and DMSO-treated cells based on RNA-seq results. (B) GSEA analysis of the mitotic spindle checkpoint in PD- (10 μM) and DMSO-treated cells. (C, D) GSEA analysis of the cell cycle (R_HSA_1640170 and HSA04110) in PD- (10 μM) and DMSO-treated cells. GO analysis of cellular components (CC) (E), molecular functions (MF) (F), and biological processes (BP) (G, H) in PD- (10 μM) and DMSO-treated cells.