TABLE 2.

The effects of rhubarb anthraquinone on serum biochemical indices in rats with acute liver injury (Mean ± s).

Index	NC	ALI	RA-L	RA-M	RA-H
ALT (U/L)	11.84 ± 4.0	54.0 ± 36.13**	48.08 ± 19.34	43.18 ± 28.96#	23.17 ± 1.57##
AST (U/L)	95.34 ± 14.81	253.75 ± 88.52**	274.1 ± 87.25	190.66 ± 10.91##	120.06 ± 43.54##
ALP(U/L)	136.32 ± 28.64	333.32 ± 19.38**	307.26 ± 74.80	299.4 ± 54.35	162.48 ± 52.17##
γ-GT (U/L)	0.32 ± 0.09	1.2 ± 0.31**	1.23 ± 0.18	1.08 ± 0.28	0.83 ± 0.08#
TC (mmol/L)	1.36 ± 0.09	1.84 ± 0.12**	1.66 ± 0.14	1.55 ± 0.16#	1.43 ± 0.14#
TG (mmol/L)	0.63 ± 0.11	2.13 ± 0.50**	1.51 ± 0.31#	1.19 ± 0.21##	0.82 ± 0.23##
LDL (mmol/L)	0.34 ± 0.02	0.51 ± 0.05*	0.46 ± 0.04	0.42 ± 0.03	0.38 ± 0.06#
HDL (mmol/L)	1.23 ± 0.08	0.56 ± 0.12**	0.58 ± 0.05	0.87 ± 0.11#	1.03 ± 0.12##

Compared with the NC, *p < 0.05, **p < 0.01, compared with the ALI.

#p < 0.05.

##p < 0.01.

Compared with the NC, the rat liver tissue activities of Hyp, MDA, IL-6, IL-8 and TNF-α in ALI were increased significantly (p < 0.05, p < 0.01), while the activities of GSH and SOD were decreased significantly (p < 0.05, p < 0.01). After administration of rhubarb anthraquinone, the rat liver tissue activities of Hyp, MDA, TNF-α and IL-6 in RA-H were significantly decreased (p < 0.05, p < 0.01), while the GSH and SOD activities were significantly increased (p < 0.05, p < 0.01). Some biochemical indexes of liver function in RA-L and RA-M also showed obvious changes, and the results were shown in Table 3