TABLE 5.

Metabolism-based analysis of metabolic pathways involved in the metabolism of characteristic metabolites.

No.	Pathway name	Match Status	Raw p	-log(p)	Impact	Details
1	Arginine and proline metabolism	2/38	0.03477	1.4588	0.05278	KEGG
2	Phenylalanine metabolism	1/12	0.091683	1.0377	0.0	KEGG
3	Butanoate metabolism	1/15	0.11337	0.9455	0.03175	KEGG
4	Alanine, aspartate and glutamate metabolism	1/28	0.20195	0.6947	0.04808	KEGG
5	Porphyrin and chlorophyll metabolism	1/30	0.21484	0.6678	0.02799	KEGG
6	Cysteine and methionine metabolism	1/33	0.23381	0.6311	0.05271	KEGG
7	Glycine, serine and threonine metabolism	1/34	0.24004	0.6197	0.03523	KEGG
8	Valine, leucine and isoleucine degradation	1/40	0.27645	0.5583	0.02264	KEGG
9	Tryptophan metabolism	1/41	0.28236	0.5492	0.01391	KEGG

Total cmpd was the total number of compounds in the pathway; Hits was the actually matched number from the user uploaded data; the Raw p was the original p-value calculated from the enrichment analysis; the Holm p was the p-value adjusted by Holm-Bonferroni method; the FDR p, was the p-value adjusted using False Discovery Rate; the Impact was the pathway impact value calculated from pathway topology analysis.