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. 2023 Feb 6;3(3):100261. doi: 10.1016/j.xgen.2023.100261

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Using scRNA-seq expression data to dissect genetic risk

(A) Multi-marker analysis of genomic annotation (MAGMA) gene set enrichment based on the scRNA-seq data showed significant associations with both dopaminergic neuron cell clusters. Colors represent the same cell types as in Figure 2C.

(B) LocusZoom plot of locus 28 with rs11950533 as the index variant. Association data are derived from the most recent PD GWAS.²

(C) Violin plot showing correlation between the genotype at rs11950533 and expression of CAMLG in the DA neuron cell cluster.

(D) LocusCompare plot of the correlation between the PD GWAS² association results and the scRNA-seq expression quantitative trait locus (eQTL) analysis.