Figure 1.

Cellular diversity of DLPFC from Alzheimer’s disease and unaffected donors revealed by single cell multiomics

(A) Experimental design.

(B) Uniform manifold approximation and projection (UMAP) visualization of the weighted nearest neighbor (WNN) clustering of single nuclei colored by cell type and cluster assignment.

(C) Total number of cells in each subcluster and the proportion of cells from each individual (red, AD donors; blue, unaffected donors) in the subcluster.

(D) Row-normalized gene expression of scREAD cell type markers.

(E) Chromatin accessibility across cell types for cell type marker genes (indicated below).

(F) Correlation of pseudo-bulked cell type-specific expression profiles between individuals. Colors indicating cell type are consistent throughout the figure.