Figure 1.

Summary of approach, key findings, and potential future directions in Pintacuda et al.

The PPI network established in this paper is derived from genes associated with ASD in the largest study of rare variation to date.⁸ PPIs in stem-cell-derived neurogenin-2 induced excitatory neurons (iNs) were then established through immunoprecipitation (IP) experiments. Key findings include neuron- and isoform-specific and recurrent protein interactions. Future directions may involve integrating cell-type-specific proteomics with other functional genomic modalities and data.