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. 2022 Aug 3;20(5):899–911. doi: 10.1016/j.gpb.2022.07.003

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Top contributing genes in cancers

A. Percentages of the top 100 contributing genes which were differentially expressed between normal and cancer tissues. Dashed lines indicate the percentage of differentially expressed genes by random chance. B. Expression levels of the top 100 contributing genes which were observed only in cancer samples, only in normal samples, and in both normal and cancer samples, of genes identified by DeepLift on aggregated MLP models (shown as MLP-Agg, representative of group II, left panel) and by Saliency on aggregated MLP models (representative of group III, right panel). C. Heatmap of the 1179 shared top contributing genes from 33 TCGA cancer types demonstrated tissue specificity.