Supplementary Figure S7.

Optimization on different model explainers A. Spearman’s correlation on gene contribution scores and (B) overlap in the top 100 contributing genes in lung (upper panel), ovary (middle panel), and pancreas (lower panel) among replicates from different pre-trained models with different gene orders on CNN. The analyses were carried out with different optimization strategies: without optimization, with optimized conditions for each explainer but without model aggregation, and with optimized conditions for each explainer and with model aggregation. C. and D. similar analysis as (A) and (B) but based on MLP.