Table 1.
Summary of clinical characteristics, laboratory data, and autopsy findingsa
| Non-Delta/Non-Omicron (n = 5) | Delta (n = 12) | Omicron (n = 5) | |
|---|---|---|---|
| Genotype confirmed by sequencing, No. (%) | 5 (100) | 8 (67) | 4 (80) |
| Clinical characteristics | |||
| Age at death, median [IQR], years | 53 [50–63] | 56 [48–65] | 67 [50–68] |
| Sex, No. (% male) | 4 (80) | 9 (75) | 1 (20) |
|
4 (80) | 6 (67) | 0 (0) |
| Vaccination, No. (%) | 0 (0) | 3 (25) | 2 (40) |
| Illness duration, median [IQR], days | 13 [9–21] | 18 [8–25] | 6 [6–9] |
| Laboratory data | |||
| Max CRP, median [IQR], mg/L | 198 [114–284] | 111 [56–175] | 120 [117–163] |
| Max ferritin, median [IQR], µg/L | 4618 [1124–9373] | 3064 [2977–10 521] | 293 [217–8583] |
| Max D-dimer, median [IQR], ng/mL | 4000 [3068–4000] | 4000 [2341–4000] | 3213 [2479–3607] |
| AST, median [IQR], U/L | 69 [68–140] | 116 [65–485] | 28 [24–191] |
| ALT, median [IQR], U/L | 109 [27–138] | 58 [44–276] | 19 [13–34] |
| GFR, median [IQR], mL/min/1.73 m2 | 16 [14–21] | 28 [26–59] | 29 [29–61] |
| WBC, median [IQR], K/μL | 16.4 [3.2–19.4] | 15.7 [10.1–26.6] | 11.3 [6.2–12.2] |
| ANC, median [IQR], K/μL | 4.0 [2.1–7.5] | 13.9 [8.2–18.9] | 8.8 [4.9–9.5] |
| ALC, median [IQR], K/μL | 0.24 [0.17–0.51] | 1.00 [0.59–3.70] | 0.75 [0.39–2.15] |
| INR, median [IQR] | 1.5 [1.4–2.1] | 1.3 [1.1–2.7] | 1.7 [1.4–2.0] |
| Autopsy findings | |||
| Postmortem interval, median [IQR], h | 40 [20–52] | 44 [28–62] | 72 [69–96] |
| Brain weight, median [IQR], g | 1460 [1380–1530] | 1325 [1243–1400] | 1180 [1150–1280] |
| Hypoxic-ischemic injury, n (%) | 5 (100) | 12 (100) | 4 (80) |
| Infarction, n (%) | 1 (20) | 2 (17) | 0 (0) |
| Hemorrhage, n (%) | 1 (20) | 4 (33) | 1 (20) |
| Microglial nodules, n (%) | 0 (0) | 2 (17) | 0 (0) |
| Thrombi, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Nucleocapsid IHC, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Spike IHC, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Spike RNA ISH, n (%) | 0 (0) | 0 (0) | 0 (0) |
| N1 RT-qPCR, n (%) | 0 (0) | 0 (0) | 0 (0) |
a
Laboratory results reflect last measured values prior to death unless otherwise specified.
Normal ranges: CRP 0.0–10.0 mg/L; ferritin female: 13–150 and male 30–400 μg/L; D-dimer <500 ng/mL; AST 10–50 (U/L), ALT 10–50 (U/L); GFP >59 ml/min/1.73 m2; WBC 4.00–10.00 K/μL; ANC 2.50–6.00 K/μL; ALC 1.00–4.80 K/μL; INR 0.9–1.1.
ALC, absolute lymphocyte count; ANC, absolute neutrophil count; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; GFR, glomerular filtration rate; INR, international normalized ratio; WBC, white blood cell count.