Table 3.
Neuropathological findings
| Patient no. | SARS-CoV-2 pango lineage | Symptom onset to death (days) | Postmortem interval (h) | Brain weight (g) | COVID-19-associated neuropathological findings |
|---|---|---|---|---|---|
| 1 | A.2 | 21 | 52 | 1290 | Mild hypoxic ischemic injury |
| 2 | B.1 | 9 | 40 | 1460 | Mild hypoxic ischemic injury |
| 3 | B.1 | 8 | 20 | 1530 | Mild hypoxic ischemic injury |
| 4 | B.1.2 | 24 | 10 | 1590 | Mild hypoxic ischemic injury |
| 5 | B.1.2 | 13 | 116 | 1380 | Scattered petechial/microhemorrhages; acute microinfarct in inferior olivary nucleus; mild hypoxic ischemic injury |
| 6 | AY.86 (Delta) | 4 | 41 | 1460 | Focal subarachnoid hemorrhage; mild to moderate hypoxic ischemic injury |
| 7 | AY.119 (Delta) | 32 | 50 | 1580 | Scattered microinfarcts with hemorrhage involving white matter throughout brain; focal microglial nodule formation in medulla; mild hypoxic ischemic injury |
| 8 | AY.47 (Delta) | 22 | 58 | 1370 | Mild hypoxic ischemic injury |
| 9 | Unknown (presumed Delta)a | 22 | 43 | 1260 | Chronic microinfarct in corpus callosum; mild hypoxic ischemic injury |
| 10 | AY.117 (Delta) | 9 | 30 | 1210 | Mild hypoxic ischemic injury |
| 11 | Unknown (presumed Delta)a | 1 | 122 | 1290 | Mild hypoxic ischemic injury |
| 12 | AY.3 (Delta) | 50 | 8 | 1020 | Mild hypoxic ischemic injury |
| 13 | Unknown (presumed Delta)a | 8 | 180 | 1250 | Subdural hemorrhage; mild hypoxic ischemic injury |
| 14 | Unknown (presumed Delta)a | 18 | 45 | 1390 | Single microglial nodule in medulla; mild hypoxic ischemic injury |
| 15 | AY.119 (Delta) | 33 | 11 | 1220 | Mild hypoxic ischemic injury |
| 16 | B.1.617.2 (Delta) | 17 | 72 | 1430 | Mild hypoxic ischemic injury |
| 17 | AY.25 (Delta) | 7 | 20 | 1360 | Mild hypoxic ischemic injury; red blood cell extravasation |
| 18 | BA.1.1 (Omicron) | 9 | 96 | 1380 | Mild hypoxic ischemic injury |
| 19 | BA.1.15 (Omicron) | 6 | 69 | 1280 | None |
| 20 | BA.1 (Omicron) | 6 | 65 | 1180 | Mild hypoxic ischemic injury |
| 21 | BA.1.1 (Omicron) | 3 | 72 | 1100 | Parenchymal microhemorrhages; subarachnoid hemorrhage; mild hypoxic ischemic injury |
| 22 | Unknown (presumed Omicron)a | 29 | 121 | 1150 | Mild hypoxic ischemic injury |
a
SARS-CoV-2 variant not confirmed by sequencing of lung tissue or nasopharyngeal swabs. These cases were assigned to Delta variant cohort if first reported COVID-19 symptoms or positive RT-PCR test were between July 1 and December 15, 2021 or to Omicron cohort if first reported symptoms or positive RT-PCR test were from December 16, 2021 to February 15, 2022.