Table 2.

Zebrafish models and their effectiveness in the study of bone diseases.

Disease Studied	Zebrafish Models	Effectiveness of the Study	Reference
Osteogenesis imperfecta (OI)	Chihuahua (chi)	Understanding the role of collagen in bone development through stress study of the endoplasmic reticulum in fibroblasts and osteoblasts	[25,26]
	frilly fins (frf)	Studying the less common form of OI caused by bmp1 mutation affecting the formation of mature collagen I	[28,29]
Osteoporosis	atp6v1h mutant	Finding a new bone formation pathway as well as identifying a possible therapy	[30]
Osteopetrosis	panther (fms)	Provides an osteopetrosis disease study model	[31]
Osteoarthritis	prg4a−/−; prg4b−/−double mutant	Studying wear and tear of cartilages present in joints due to depletion of lubricating proteins of synovial joints	[32]
Fibrodysplasia Ossificans Progressiva (FOP)	acvr1-alk2 mutant	Studying the role of acvr in dorsoventral patterning and understanding its role in the disease	[33]
Scoliosis	fused somites (fss)	Understanding the role of the Delta-Notch pathway in the progression of the disease	[34]
	leviathan	Study of the possibility of genetic factors playing a role in the disease	[35]
	zmynd10, ift88, kif3b, uts2ra mutant	Establishing a correlation between scoliosis and Parkinson's disease	[36]
Ankylosing spondylitis (AS) Klippel-Feil syndrome (KFS)	dolphin, stocksteif	Understanding the possible role of cyp26b1 in AS and KFS	[37]
Craniosynostosis	stocksteif	Understanding that osteoblast differentiation defects can induce the disease	[44]
	tcf12/twist1b double mutant	Using CRISPR technology for understanding the disease progression	[38]