Figure 2.

Efficiency of rAAV2.5T redosing to ferret lung

Secreted gLuc expression in (A) BALF and (B) plasma following intratracheal delivery of rAAV2.5T-fCFTRΔR to 4-week-old ferrets, followed by rAAV2.5T-gLuc 4 weeks later. BALF was harvested 14 days after rAAV2.5T-gLuc delivery, and plasma was harvested at the indicated time points. Results are presented as the mean ± SEM. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test using log2-transformed data, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. ns, not significant. n = 15 animals per group.