Figure 3.

Level of AAV2.5T-specific neutralizing antibody (NAb) in BALF and plasma following AAV2.5T redosing

NAb titers in the (A) BALF and (B) plasma following intratracheal delivery of rAAV2.5T-fCFTRΔR at 4 weeks of age, followed by rAAV2.5T-gLuc 4 weeks later. Results showed as mean ± SEM. The average NAb titer of the naive group was below the limits of detection in both BALF and plasma. Statistical significance was analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test using log2(Y+1)-transformed data, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. ns, not significant. n = 15 animals in each group.