Fig. 3.

The effect of α-KG on mitophagy of human chondrocytes induced by IL-1β. (A–B) Volcano plot showing changes in RNA expression; (C) KEGG analysis of RNA sequencing after α-KG treatment in IL-1β induced chondrocytes; (D) TEM was used to assay the mitophagy before and after α-KG treatment in IL-1β induced chondrocytes, and normal (black arrow), swelling (white arrow), and autophagic (red arrow) mitochondria were as indicated; (E) Colocalization of mitochondria and lysosomes in chondrocytes, scale bar = 25 μm, n = 3. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)