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. 2023 Mar 16;15:17588359231160141. doi: 10.1177/17588359231160141

Figure 2.

Figure 2.

Binding of different inhibitors on KRASG12C. (a) Molecular structure of sotorasib, adagrasib, and JDQ443. (b) Two different angles of aligned GDP with aligned sotorasib, adagrasib, and JDQ443 on KRASG12C. (c) Illustration of how different KRAS-G12Ci binding impacts KRAS protein conformation. (d) Two different angles of sotorasib, adagrasib, and JDQ443 binding on GDP-KRASG12C with several key KRAS residues highlighted. AMG 510 (PDB: 6OIM); MRTX849 (PDB: 6UT0); JDQ443 (PDB: 7R0M). Images were generated using PyMol version 2.5.2.