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Cartoon representations of the overall structures of tetraspanin CD81 alone and in complex with the B-cell coreceptor CD19.
A) Crystal structure of CD81 (PDB: 5TCX) reveals a cholesterol binding pocket.
B) Cryo-EM structure of the CD81/CD19 complex (PDB: 7JIC). The CTD of CD19 and the flexible linker between CTD of CD19 and TM1 of CD81 are shown as schematic representations.
