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. Author manuscript; available in PMC: 2023 Mar 20.
Published in final edited form as: Chem Rev. 2022 Jun 17;122(17):13952–13988. doi: 10.1021/acs.chemrev.1c01035

Figure 8.

Figure 8.

Overall structure of full-length IGF2R in the apo and IGF2-bound states.

A) Cryo-EM structure of apo-IGF2R (PDB: 6UM1). The 15 domains in ECD are organized into an elongated helix-like assembly.

B) Cryo-EM structure of the 1:1 IGF2R/IGF2 complex (PDB: 6UM2). Domains 1-14 rearrange into a pistol-like conformation. Domain 15 becomes disordered and is missing in the EM density. IGF2R (blue) is shown in cartoon representation, whereas the ligand IGF2 is shown in surface representation with semi-transparency. The missing domains in each structure are shown as schematic representations.