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. 2023 Mar 20;55(3):653–664. doi: 10.1038/s12276-023-00964-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a tSNE plot of pseudobulk gene expression values for CMs/IMs in each sample. Colors represent individual patients. Arrows indicate the progression of time. Six patients with a pretreatment sample are labeled with text. b HALLMARK pathway enrichment analysis of genes downregulated by corticosteroid treatment. Padj, adjusted P value. c–f Expression of genes related to key signaling pathways. Left, dot plots depicting the percentage of cells in which the gene was detected (“Percent Expressed”) and average expression level of the gene (scaled data) in each cluster (blue, “Average Expression”). Right, ridge plots depicting the expression of genes changed between pre- and post-corticosteroid treatment.