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. 2023 Mar 20;55(3):653–664. doi: 10.1038/s12276-023-00964-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Gene set enrichment analysis of TRRUST transcription factors for genes downregulated by corticosteroid treatment. Padj, adjusted P value. b Expression of STAT1 and STAT2 in longitudinal samples obtained during the course of corticosteroid treatment. Colors represent individual patients. Error bars indicate the SD. c Dot plots showing p-ISGs and u-ISGs changed between pre- and post-corticosteroid treatment. Dot size indicates the percentage of cells in which the gene was detected (“Percent Expressed”). Color indicates the average expression level of the gene (scaled data) in each cluster (“Average Expression”). d Gene set enrichment analysis of p-ISGs and u-ISGs changed between pre- and post-corticosteroid treatment. NES, normalized enrichment score; Padj, adjusted P value. e Trajectory plots for CMs/IMs from samples collected pre- and post-corticosteroid treatment. Cells were ordered by the expression of u-ISGs. Colors represent pseudotime (left) or samples (right).