Fig. 6.

Schematic diagram of an integrated pharmacology framework for discovery of bioactivity-correlated constituents, target identification and action mechanism of herbal medicine and natural products. The first stage discovers active compounds of treatment-related herbs followed by construction of correlation analysis network of treatment-related herb-compound and small molecule metabolite (Correlations based on the abundance scored value). Next is that highlight the main active constituents from identification of new candidates from natural products, and then elucidate the underlying mechanisms by target virtual screening and identification, until the final step of in vitro and in vivo tests. The images were obtained using the example data provided by the MetaboAnalyst 5.0 and figures created by BioRender