TABLE 1.
Baseline patient characteristics
| Moderate Cognitive Impairment n = 40 | Normal Cognition n = 40 | P‐value | |
|---|---|---|---|
| Age | 66.6 ± 8.0 | 62.9 ± 10.0 | 0.066 |
| Gender (M/F) | 35/5 | 33/7 | 0.756 a |
| Disease duration (yrs) | 11.1 ± 4.8 | 11.6 ± 5.6 | 0.655 |
| Education (yrs) | 13.4 ± 3.4 | 15.5 ± 2.6 | 0.002 |
| DRS‐2 score | 126.3 ± 8.7 | 139.3 ± 3.3 | <0.001 |
| UPDRS I | 3.1 ± 2.0 | 1.9 ± 1.4 | 0.004 |
| UPDRS II* | 17.8 ± 7.8 | 13.9 ± 6.7 | 0.019 |
| UPDRS III off med | 42.2 ± 12.5 | 35.6 ± 10.4 | 0.012 |
| UPDRS III on med | 18.7 ± 9.5 | 14.9 ± 8.8 | 0.078 |
| UPDRS IV | 6.2 ± 3.5 | 7.1 ± 3.1 | 0.246 |
| LEDD (mg) | 1238 ± 631 | 1410 ± 771 | 0.279 |
| UPDRS part III change with medications | 56 ± 16% | 59 ± 15% | 0.513 |
| DBS target | 0.007 a | ||
| STN | 12 (30%) | 25 (63%) | |
| GPi | 22 (55%) | 15 (37%) | |
| ViM | 6 (15%) | 0 (0%) | |
| Surgery staging | 0.013 a | ||
| Bilateral simultaneous | 5 STN, 1 GPi (15%) | 9 STN, 8 GPi (43%) | |
| Unilateral | 6 STN, 16 GPi, 4 ViM (65%) | 12 STN, 7 GPi (47%) | |
| Staged (within 1 yr) | 1 STN, 5 GPi, 2 ViM (20%) | 4 STN (10%) | |
| Surgery method | 0.494 a | ||
| Awake with MER | 22 (55%) | 26 (65%) | |
| Under anesthesia in iMRI | 18 (45%) | 14 (35%) | |
| Number of surgical risk factor comorbidities | 0.9 ± 0.8 | 0.6 ± 0.7 | 0.052 |
| Baseline to follow‐up (mo) | 15.9 ± 5.4 | 16.7 ± 4.9 | 0.487 |
| Surgery to follow‐up (mo) | 10.4 ± 4.0 | 11.1 ± 3.7 | 0.400 |
Note: p = <.01
Abbreviations: MER, microelectrode recordings; iMRI, interventional MRI.
a
2 × 2 Fisher exact test (STN vs GPi/ViM; Bilateral vs Unilateral/Staged).
b
combined score off and on medications (see Methods).