TABLE 1.

Relationship of clinical results and NOTCH1 and SF3B1 mutations

				NOTCH1					SF3B1
		Total patients		Mutated		Wild‐type			Mutated		Wild‐type
		No	%	No	%	No	%	Sig‐No	No	%	No	%	Sig‐No
Subject	Number of patients	51	100	8	16	43	84		9	18	42	82
Sex	Male	33	65	4	12	29	88	0.43	6	18	27	82	1
	Female	18	35	4	22	14	78		3	17	15	83
Age	>60 year	24	47	5	21	19	79	0.451	4	17	20	83	1
	<60 year	27	53	3	11	24	89		5	19	22	81
Swelling lymph node	>3 nodes	20	39	4	20	16	80	0.696	5	25	15	75	0.289
	<3 nodes	31	61	4	13	27	87		4	13	27	87
WBC count	>100 (103/μl)	7	14	1	14	6	86	1	2	29	5	71	0.592
	<100 (103/μl)	44	86	7	16	37	84		7	16	37	84
Lymphocyte count	>5 (103/μl)	48	94	8	17	40	83	1	8	17	40	83	0.449
	<5 (103/μl)	3	6	0	0	3	100		1	33	2	67
Hb	>11 (g/dL)	43	84	6	14	37	86	0.595	9	21	34	79	0.322
	<11 (g/dL)	8	16	2	25	6	75		0	0	8	100
Hct	>33%	43	84	6	14	37	86	0.595	9	21	34	79	0.322
	<33%	8	16	2	25	6	75		0	0	8	100
Plt count	>100 (103/μl)	42	82	6	14	36	86	0.619	8	19	34	81	1
	<100 (103/μl)	9	18	2	22	7	78		1	11	8	89
Smudge and basket cell	Present	40	78	6	15	34	85	1	6	15	34	85	0.385
	Absent	11	22	2	18	9	82		3	27	8	73
Smudge and basket cells grade	Zero	11	22	2	18	9	82	0.833	3	27	8	73	0.705
	Few	18	35	2	11	16	89		2	11	16	89
	Few to moderate	2	4	0	0	2	100		0	0	2	100
	Moderate	17	33	3	18	14	82		3	18	14	82
	Many	3	6	1	33	2	67		1	33	2	67
Pro‐lymphocyte	Present	15	29	3	20	12	80	0.679	5	33	10	67	0.102·
	Absent	36	71	5	14	31	86		4	11	32	89
Staging binet	A	33	65	4	12	29	88	0.142·	4	12	29	88	0.096·
	B	14	27	2	14	12	86		5	36	9	64
	C	4	8	2	50	2	50		0	0	4	100
Immunophenotype	CLL	32	64	0	0	32	100	<0.0001··	5	16	27	84	1
	aCLL	18	36	8	44	10	56		3	17	15	83
CD38 expression	Positive	13	25	5	38	8	62	0.019··	3	23	10	77	0.676
	Negative	38	75	3	8	35	92		6	16	32	84

Abbreviations: TS(·), tendency to significant; S(··), significant.