Table 2.
Predictive accuracy of urinary biomarkers on day 0 for renal non-recovery
| Urinary Biomarkers | AUC | p value | Cutoff | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | |||
| [TIMP-2] × [IGFBP7] | 0.78 | < 0.001 | 0.72 (ng/mL)2/1000 | 65.6 | 85.0 |
| (0.71–0.84) | (52.7–77.1) | (76.5–91.4) | |||
| CCL14 | 0.71 | < 0.001 | 625.69 (pg/mL) | 65.6 | 72.0 |
| (0.63–0.77) | (52.7–77.1) | (62.1–80.5) | |||
| NGAL | 0.53 | 0.562 | 37.69 (pg/mL) | 34.4 | 81.0 |
| (0.45–0.60) | (22.9–47.3) | (71.9–88.2) | |||
| [TIMP-2] × [IGFBP7] + CCL14 | 0.77 | < 0.001 | 0.224 | 90.6 | 51.0 |
| (0.70–0.83) | (80.7–96.5) | 40.8–61.1 |
Day 0 means the day of AKI diagnosis. AUC area under the receiver operating characteristic, CI confidence interval, TIMP-2 tissue inhibitor of metalloproteinases-2, IGFBP-7 insulin-like growth factor-binding protein 7, CCL14 C–C motif chemokine ligand 14, NGAL neutrophil gelatinase-associated lipocalin