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. 2023 Mar 20;11:32. doi: 10.1186/s40364-023-00472-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — BCL7A methylation and expression status in AML patients and cell lines. a Significant inverse correlation (Pearson’s correlation coefficient) between methylation and expression of BCL7A in TCGA-LAML cohort, TARGET-AML and Glass et al. Methylation is expressed as the beta-value of the Illumina HM450 probe (TCGA, TARGET) or genomic position (Glass et al.) most inversely correlated with gene expression. b CpG methylation profile around the transcription start site (TSS) of BCL7A in AML cell lines. Methylation fraction measured by reduced representation bisulfite sequencing data from DepMap Portal (https://depmap.org/portal/) is shown along with our bisulfite sequencing data of the NB4 cell line (top row). CpGs significantly correlated with expression (FDR < 0.05) are highlighted under grey background and their Pearson’s correlation coefficient is shown above. The TSS of BCL7A is indicated by a vertical line. c Methylation fraction 1 kb upstream of the BCL7A TSS and gene expression in 32 AML cell lines from DepMap Portal. NB4 shows the highest methylation level as well as low BCL7A expression