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. Author manuscript; available in PMC: 2023 Mar 20.
Published in final edited form as: Ann Rheum Dis. 2016 Oct 18;76(4):731–739. doi: 10.1136/annrheumdis-2016-209206

Figure 4. The obese arthritic mice demonstrate delayed remission compared to their counterpart controls.

Figure 4.

A. Ankle circumference was determined in wild type (WT) mice that were fed on RD or 60% HFD for 10 weeks following i.a. injection with 10 μg of LPS and mice were sacrificed after 72h of LPS injection, n=10. B. RD and HFD ankles harvested after 72h of LPS injection were H&E stained (orig. mag. x 200), and C. inflammation, lining thickness and bone erosion were quantified on a 0-5 scale, n=10. D. % lean mass and fat mass were assessed by DXA in TLR4 mediated arthritis mice (72h) fed on RD and HFD, n=10. E. Protein levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6 and MIP2) and F. chemokines (CXCL1, CXCL5, CCL2, CCL3, CCL20 and CCL5) were quantified by ELISA in TLR4 arthritic mice (72h) fed on RD and HFD, n=5. Values are mean ± SE. * indicates p<0.05.