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. Author manuscript; available in PMC: 2023 Jul 16.
Published in final edited form as: Nat Cardiovasc Res. 2023 Jan 16;2:144–158. doi: 10.1038/s44161-022-00206-6

Figure 2. CHIP and incident pan-arterial atherosclerosis risk.

Figure 2.

a) Association of CHIP with 9 total incident atherosclerotic diseases separately and combined in a ‘Pan-arterial atherosclerosis’ phenotype in the UKB, MGBB, and meta-analyzed across both studies (“Overall”). Error bars are centered at the HR and show the 95% CI for estimates. b) Cumulative risk of incident atherosclerosis across the composite ‘pan-arterial atherosclerosis’ phenotype stratified by no CHIP, small CHIP (VAF<10%), and large CHIP (VAF≥10%) carrier state in the UK Biobank (N=37,657). c) Association of CHIP VAF with fraction of individuals developing pan-arterial atherosclerosis in the UK Biobank (N=37,657). Error bands reflect the standard error of a generalized binomial additive model with integrated smoothness fit to the data.

CHIP = clonal hematopoiesis of indeterminate potential; VAF = variant allele fraction; PAD = peripheral artery disease