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. Author manuscript; available in PMC: 2023 Jul 16.
Published in final edited form as: Nat Cardiovasc Res. 2023 Jan 16;2:144–158. doi: 10.1038/s44161-022-00206-6

Figure 3: Gene-specific association of CHIP with incident peripheral artery disease (PAD).

Figure 3:

a) CHIP-PAD association analyses stratified by putative CHIP driver gene. Results following meta-analysis across the UKB and MGBB (N=50,122) are shown. Error bars are centered at the HR and show the 95% CI for estimates. b) Gene-specific comparison of HR and 95% CI for hematologic malignancy (x-axis) and PAD (y-axis) in the UKB (N=37,657). Error bars are centered at the HR and show the 95% CI for estimates. c) Association of DDR CHIP (PPM1D or TP53) with incident peripheral artery disease, coronary artery disease, and pan-vascular atherosclerosis. Results across UK Biobank (N=37,657) and MGB Biobank (N=12,465) were combined using an inverse-variance weighted fixed effects meta-analysis. Error bars are centered at the HR and show the 95% CI for estimates. CHIP = clonal hematopoiesis of indeterminate potential; DDR = DNA-damage repair; VAF = variant allele fraction; PAD = peripheral artery disease