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. Author manuscript; available in PMC: 2023 Jul 16.
Published in final edited form as: Nat Cardiovasc Res. 2023 Jan 16;2:144–158. doi: 10.1038/s44161-022-00206-6

Extended Data Figure 1. Association of CHIP with blood counts among individuals without prevalent hematologic malignancy in the UK Biobank (n=37,657).

Extended Data Figure 1.

Blood counts were acquired at time of blood draw for whole exome sequencing. a) Association of CHIP and Large CHIP with normalized blood counts (SD). Associations are adjusted for age, age2, sex, smoking status, and the first ten principal components of genetic ancestry. b) Association of CHIP variant allele frequency (VAF) with blood counts (in units of 10^9 cells/L). The gray horizontal dotted lines reflect average counts across non-CHIP carriers. The vertical black dotted line reflects the cutoff VAF for Large CHIP (VAF>0.1). Error bands reflect the standard error of a generalized additive model with integrated smoothness fit to the data. CHIP = clonal hematopoiesis of indeterminate potential; VAF = variant allele fraction