Skip to main content
. 2023 Mar 15;12(1):2185456. doi: 10.1080/22221751.2023.2185456

Table 1.

Characteristics of HE or HPV vaccinees who became pregnant throughout the study.

Characteristic HE vaccine group HPV vaccine group p-value
Pregnant women      
  No. 1263 1259
  Median follow-up months (IQR) 68.5 (66.6,69.4) 68.2 (66.6,69.3) 0.5947
  No. of pregnancy (%)     0.8479
     1 905 (71.7) 918 (72.9)  
     2 298 (23.6) 283 (22.5)  
     3 53 (4.2) 53 (4.2)  
     ≥4 7 (0.6) 5 (0.4)  
Pregnancy events      
  No. 1684 1660
  Median maternal age (IQR) 28.0 (26.0, 30.0) 28.0 (26.0, 31.0) 0.1094
  Distribution of maternal age-No. (%)     0.0608
   <35 1505 (89.4) 1449 (87.3)  
   ≥35 179 (10.6) 211 (12.7)  
  Site distribution-No. (%)     0.1087
   Liuzhou City 753 (44.7) 719 (43.3)  
   Funing County 388 (23.0) 446 (26.9)  
   Xinmi County 305 (18.1) 267 (16.1)  
   Fengning County 131 (7.8) 130 (7.8)  
   Yangcheng County 107 (6.4) 98 (5.9)  
  Vaccination during pregnancy*-No. (%)     0.3040
   Yes 66 (3.9) 77 (4.6)  
   No 1618 (96.1) 1583 (95.4)  
  Median interval months between the onset of pregnancy and the last vaccination (IQR) 23.8 (10.8, 37.8) 22.7 (9.1 37.9) 0.2164
  Classification of vaccination exposure -No. (%)     0.4376
   Proximal 213 (12.6) 225 (13.6)  
   Distal 1471 (87.4) 1435 (86.4)  

*Only one woman in HE vaccine group received more than one vaccination (two doses, first and second) during the same pregnancy event, and her stage of gestational vaccine exposure was defined as the stage at the time of the first dose. The gestational stage of vaccine exposure was the first trimester for all pregnancy events with vaccination during pregnancy.

Data were calculated only for those events without vaccine exposure during pregnancy.

Proximal exposure was defined as vaccination during pregnancy or the onset of pregnancy within 90 days post any dose.

Abbreviations: HE, hepatitis E; HPV, human papillomavirus; No., number; IQR, interquartile range.