Table 1.
Characteristic | HE vaccine group | HPV vaccine group | p-value | |
---|---|---|---|---|
Pregnant women | ||||
No. | 1263 | 1259 | – | |
Median follow-up months (IQR) | 68.5 (66.6,69.4) | 68.2 (66.6,69.3) | 0.5947 | |
No. of pregnancy (%) | 0.8479 | |||
1 | 905 (71.7) | 918 (72.9) | ||
2 | 298 (23.6) | 283 (22.5) | ||
3 | 53 (4.2) | 53 (4.2) | ||
≥4 | 7 (0.6) | 5 (0.4) | ||
Pregnancy events | ||||
No. | 1684 | 1660 | – | |
Median maternal age (IQR) | 28.0 (26.0, 30.0) | 28.0 (26.0, 31.0) | 0.1094 | |
Distribution of maternal age-No. (%) | 0.0608 | |||
<35 | 1505 (89.4) | 1449 (87.3) | ||
≥35 | 179 (10.6) | 211 (12.7) | ||
Site distribution-No. (%) | 0.1087 | |||
Liuzhou City | 753 (44.7) | 719 (43.3) | ||
Funing County | 388 (23.0) | 446 (26.9) | ||
Xinmi County | 305 (18.1) | 267 (16.1) | ||
Fengning County | 131 (7.8) | 130 (7.8) | ||
Yangcheng County | 107 (6.4) | 98 (5.9) | ||
Vaccination during pregnancy*-No. (%) | 0.3040 | |||
Yes | 66 (3.9) | 77 (4.6) | ||
No | 1618 (96.1) | 1583 (95.4) | ||
Median interval months between the onset of pregnancy and the last vaccination (IQR)† | 23.8 (10.8, 37.8) | 22.7 (9.1 37.9) | 0.2164 | |
Classification of vaccination exposure‡ -No. (%) | 0.4376 | |||
Proximal | 213 (12.6) | 225 (13.6) | ||
Distal | 1471 (87.4) | 1435 (86.4) |
*Only one woman in HE vaccine group received more than one vaccination (two doses, first and second) during the same pregnancy event, and her stage of gestational vaccine exposure was defined as the stage at the time of the first dose. The gestational stage of vaccine exposure was the first trimester for all pregnancy events with vaccination during pregnancy.
Data were calculated only for those events without vaccine exposure during pregnancy.
Proximal exposure was defined as vaccination during pregnancy or the onset of pregnancy within 90 days post any dose.
Abbreviations: HE, hepatitis E; HPV, human papillomavirus; No., number; IQR, interquartile range.