The absorption and distribution properties prediction of isatin-based Schiff bases 3b and 5a–c.
| Properties | 3b | 5a | 5b | 5c |
|---|---|---|---|---|
| Absorption | ||||
| Caco-2 permeability (log cm s−1) | −4.781/
|
−4.699/
|
−4.842/
|
−4.827/
|
| MDCK permeability (cm s−1) | 1.7 × 10−5/
|
2.1 × 10−5/
|
1.6 × 10−5/
|
1.4 × 10−5/
|
| P-glycoprotein-inhibitor | 0.013/
|
0.001/
|
0.304/
|
0.799/
|
| P-glycoprotein-substrate | 0.017/
|
0.003/
|
0.001/
|
0.001/
|
| Distribution | ||||
| Plasma protein binding (PPB, %) | 100.3/
|
98.68/
|
100.6/
|
100.8/
|
| Fraction unbound in plasma (FU, %) | 1.268/
|
2.537/
|
1.423/
|
1.586/
|
| Volume distribution (VD, L kg−1) | 0.987/
|
1.964/
|
0.476/
|
0.39/
|