Table 5.
Herpes zoster-associated medication types in participants with confirmed herpes zoster.
| Medication class | ZOE-50 | ZOE-70 | ZOE-HSCT* | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RZV | Placebo | Total | RZV | Placebo | Total | RZV | Placebo | Total | ||||||||||
| (N = 9) | (N = 254) | (N = 263) | (N = 23) | (N = 223) | (N = 246) | (N = 49) | (N = 135) | (N = 184) | ||||||||||
| n | % | n | % | n | % | n | % | n | % | n | % | n | % | n | % | n | % | |
| Nonopioids† | 6 | 66.7 | 155 | 61.0 | 161 | 61.2 | 6 | 26.1 | 103 | 46.2 | 109 | 44.3 | 22 | 44.9 | 62 | 45.9 | 84 | 45.7 |
| Weak opioids† | 0 | 0 | 49 | 19.3 | 49 | 18.6 | 2 | 8.7 | 30 | 13.5 | 32 | 13.0 | 6 | 12.2 | 34 | 25.2 | 40 | 21.7 |
| Strong opioids† | 0 | 0 | 21 | 8.3 | 21 | 8.0 | 0 | 0 | 5 | 2.2 | 5 | 2.0 | 5 | 10.2 | 12 | 8.9 | 17 | 9.2 |
| Corticosteroids | 3 | 33.3 | 21 | 8.3 | 24 | 9.1 | 1 | 4.3 | 10 | 4.5 | 11 | 4.5 | 2 | 4.1 | 14 | 10.4 | 16 | 8.7 |
| Antidepressants | 0 | 0 | 17 | 6.7 | 17 | 6.5 | 1 | 4.3 | 18 | 8.1 | 19 | 7.7 | 3 | 6.1 | 13 | 9.6 | 16 | 8.7 |
| Psychiatric medications | 0 | 0 | 29 | 11.4 | 29 | 11.0 | 2 | 8.7 | 25 | 11.2 | 27 | 11.0 | 3 | 6.1 | 29 | 21.5 | 32 | 17.4 |
| Gabapentinoids | 0 | 0 | 32 | 12.6 | 32 | 12.2 | 1 | 4.3 | 17 | 7.6 | 18 | 7.3 | 5 | 10.2 | 16 | 11.9 | 21 | 11.4 |
| Anesthetics | 0 | 0 | 15 | 5.9 | 15 | 5.7 | 0 | 0 | 11 | 4.9 | 11 | 4.5 | 0 | 0 | 7 | 5.2 | 7 | 3.8 |
| Antihistamines | 0 | 0 | 10 | 3.9 | 10 | 3.8 | 1 | 4.3 | 9 | 4.0 | 10 | 4.1 | 1 | 2.0 | 11 | 8.1 | 12 | 6.5 |
| GI medications | 1 | 11.1 | 24 | 9.4 | 25 | 9.5 | 0 | 0 | 6 | 2.7 | 6 | 2.4 | 2 | 4.1 | 2 | 1.5 | 4 | 2.2 |
| Antibiotics | 1 | 11.1 | 37 | 14.6 | 38 | 14.4 | 2 | 8.7 | 32 | 14.3 | 34 | 13.8 | 5 | 10.2 | 14 | 10.4 | 19 | 10.3 |
| Muscle relaxants | 0 | 0 | 1 | 0.4 | 1 | 0.4 | 0 | 0 | 2 | 0.9 | 2 | 0.8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other medications | 3 | 33.3 | 54 | 21.3 | 57 | 21.7 | 3 | 13.0 | 42 | 18.8 | 45 | 18.3 | 6 | 12.2 | 19 | 14.1 | 25 | 13.6 |
*
This analysis excluded medication linked to a confirmed HZ case after relapse of the pre-existing malignant disease.
†
Based on the World Health Organization's pain relief ladder.34
GI, gastro-intestinal; HSCT, hematopoietic stem cell transplantation; HZ, herpes zoster; N, number of participants with at least 1 confirmed HZ episode; n and %, number and percentage of participants with at least 1 confirmed HZ episode taking at least 1 HZ-associated medication of a given type; RZV, recombinant zoster vaccine; ZOE, Zoster Efficacy Study.