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. Author manuscript; available in PMC: 2023 Mar 20.
Published in final edited form as: Cell Rep. 2023 Jan 23;42(1):112021. doi: 10.1016/j.celrep.2023.112021

Figure 2. EpiLSCs show distinct chromatin accessibility associated with formative pluripotency and germline potency.

Figure 2.

(A) Correlation heatmap of ESCs, EpiLSCs, EpiLCs, and EpiSCs. Label 1 and 2 means two replicates.

(B) PCA plot of ESCs, EpiLSCs, EpiLCs, and EpiSCs. Each cell line has two replicates as shown with the two dots.

(C) Left: heatmap of the three clusters of differential peaks in ESCs, EpiLSCs, EpiLCs, and EpiSCs. 2 kb flanking regions were included. Right: scaled value of the peaks showing different trend in the three clusters; n stands for peak number.

(D) Enriched motif and pathway of the three clusters of differential peaks.

(E) Track plot of ATAC-seq openness at the selected loci.

(F) Average openness of the TSS regions of super-bivalent genes. Flanking regions of 10 kb were included.

(G) Heatmap of scaled ATAC-seq normalized counts in the TSS regions of the selected genes. The genes were annotated as super-bivalent and PGC-related genes.

(H) Heatmap of scaled ATAC-seq normalized counts of EpiLSCs and EpiSCs in TSS regions of Wnt pathway-related genes.

See also Figure S2 and Table S1.