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. 2023 Mar 12;24(1):2166763. doi: 10.1080/15384047.2023.2166763

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Tumor cell ICD is induced by RT and ERAD inhibitors, which can stimulate the immune system to kill cancer cells. — Mechanisms of ERAD inhibitor combined with RT in regulating ICD. ATP: adenosine 5’-triphosphate; CALR: calreticulin; DAMPs: damage-associated molecular patterns; DCs: dendritic cells; ERAD: endoplasmic reticulum associated protein degradation; ESCC: esophageal squamous cell carcinoma; HMGB1: high mobility group protein B1; ICD: immunogenic cell death; RT: radiation therapy.