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. 2023 Mar 7;19(1):2186110. doi: 10.1080/21645515.2023.2186110

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Cellular immune response induced by S-Trimer antigen in mice. BALB/c mice (n = 5/group) were immunized with various doses of S-Trimer that was non-adjuvanted or adjuvanted with CpG 7909 (10, 150, 200, 300 μg) and Al(OH)₃ (150 μg) twice on D 0 and 21. The cellular immune responses on D 42 were assessed by ELISpot. *p < .05 were considered significant when compared to 1 μg S group; #p < .05, compared to 3 μg S group; & p < .05, compared to 10 μg S group. The number at the top of each bar represents the geometric mean titer (GMT).