Figure 9.
CircSCN8A suppresses the growth of NSCLC cells in vivo. A549 cells transfected with Lv-circSCN8A or Lv-vector were subcutaneously injected into the right flanks of nude mice. (a) from the 7th day after cell inoculation, tumor growth was monitored every 6 days. (b) at 31 days after cell inoculation, tumors were excised for weight measurement. (c) the expression levels of circSCN8A, miR-1290, and ACSL4 mRNA in xenografted tumors. (d) IHC analysis of Ki-67, E-cadherin, ACSL4, and GPX4 in subcutaneous xenograft tumors. (e) Schematic diagram of the circScn8a/mir-1290/ACSL4 regulatory axis in NSCLC progression and ferroptosis. Scale bar: 100 μm. ***P <0.001.