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. 2023 Mar 6;14:1106837. doi: 10.3389/fimmu.2023.1106837

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Copyright © 2023 Leung, Cohen, Mu, Rosa Duque, Cheng, Wang, Wang, Zhang, Zhang, Tam, Lam, Chan, Chaothai, Kwan, Chan, Li, Luk, Tsang, Chu, Wong, Mori, Leung, Valkenburg, Peiris, Tu and Lau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-inferiority hypothesis testing of humoral and cellular immunogenicity outcomes against wild-type SARS-CoV-2 after the third dose of CoronaVac in evaluable analysis population. (A) Non-inferiority testing of SARS-CoV-2 Spike (S) IgG, S-receptor binding domain (S-RBD) IgG, surrogate virus neutralization test (sVNT), plaque reduction neutralization test (PRNT), S IgG avidity, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, Nucleocapsid (N) IgG, and N-C-terminal domain (N-CTD) IgG (B Non-inferiority testing of total S, N and Membrane (M) protein-specific interferon-γ (IFN-γ)+ and interleukin-2 (IL-2)+ CD4+ and CD8+ T cells Geometric mean ratios (GMR) and two-tailed 95% confidence intervals (CI) were plotted.