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. 2023 Mar 6;14:1106837. doi: 10.3389/fimmu.2023.1106837

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Copyright © 2023 Leung, Cohen, Mu, Rosa Duque, Cheng, Wang, Wang, Zhang, Zhang, Tam, Lam, Chan, Chaothai, Kwan, Chan, Li, Luk, Tsang, Chu, Wong, Mori, Leung, Valkenburg, Peiris, Tu and Lau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Omicron BA.1-specific humoral and cellular immunogenicity after the third dose of CoronaVac in healthy evaluable adolescents and adults. (A) Wild-type (WT) and BA.1 SARS-CoV-2 Spike (S) IgG OD450 values, S IgG avidity index, and S IgG Fcγ receptor IIIa (FcγRIIIa)-binding OD450 values, and 50% plaque reduction neutralization titers (PRNT). (B-D) Separate S, N and Membrane (M) protein WT reference pool and BA.1 mutation pool-specific interferon-γ (IFN-γ)+ and interleukin-2 (IL-2)+ CD4+ and CD8+ T cell frequencies. Samples from the same participant were paired between WT and BA.1 and compared with paired t test after natural logarithmic transformation with p-values denoted (*, P<0.05; **, P<0.01; ****, P<0.0001; ns, not significant).