TABLE 2.
Prevalence and Relative Risks of Gynecological and Gastrointestinal Disorders Found in 455 Women and Girls With LS and Their 4,550 Controls
| Comorbidity | ICD-10 | Prevalence in 455 women and girls with LS, % (n) | Prevalence in 4,550 controls, % (n) | RR | 95% CI | p |
|---|---|---|---|---|---|---|
| Gynecological disorders | ||||||
| Menstrual disorders (menorrhagia and postmenopausal bleeding combined) |
N92 N95.0 | 10.8 (49) | 4.4 (200) | 2.5 | 1.9–3.2 | <0.001 |
| Inflammation of vagina and vulva | N76 | 10.3 (47) | 0.8 (36) | 13.1 | 9.4–18.2 | <0.001 |
| Anogenital condyloma ± vulvar LSIL | A63.0 N90.0 | 6.6 (30) | 0.8 (37) | 8.1 | 5.1–13.0 | <0.001 |
| Pain syndromes | ||||||
| Dyspareunia | N94.1 | 1.3 (6) | 0.1 (3) | 20.0 | 7.5–53.1 | <0.001 |
| Interstitial cystitis | N30.1 | 1.3 (6) | 0.3 (12) | 5.0 | 2.1–12.1 | <0.001 |
| Urinary disorders | ||||||
| Urinary incontinence | N39.3 N39.4 R32 | 6.6 (30) | 1.4 (62) | 4.8 | 3.3–7.0 | <0.001 |
| Gastrointestinal disorders | ||||||
| Obesity | E66 | 7.9 (36) | 1.8 (80) | 4.5 | 3.2–6.4 | <0.001 |
| Diseases of lip and oral mucosa | K13 | 2.9 (13) | 0.6 (27) | 4.8 | 2.7–8.7 | <0.001 |
| Crohn disease | K50 | 0.4 (2) | 0.4 (16) | 1.3 | 0.3–5.4 | 0.77 |
| Diverticular disease of the intestine | K57 | 7.5 (34) | 4.0 (183) | 1.9 | 1.3–2.6 | <0.001 |
| Functional intestinal disorders | K59 | 3.1 (14) | 1.3 (60) | 2.3 | 1.3–4.1 | 0.003 |
| Celiac disease | K90.0 | 2.9 (13) | 0.4 (19) | 6.8 | 3.7–12.5 | <0.001 |
| Ulcerative colitis | K51 | 0.7 (3) | 0.9 (43) | 0.7 | 0.2–2.2 | 0.54 |
| Fissures of anal and rectal regions | K60 | 1.3 (6) | 0.6 (25) | 2.4 | 1.0–5.7 | 0.046 |